Celebrex celecoxib is a nonsteroidal anti-inflammatory drug (NSAID). This medicine is used to relieve symptoms of osteoarthritis (the arthritis caused by age-related “wear and tear” on bones and joints), relieve symptoms of rheumatoid arthritis in adults, manage acute pain in adults (like the short term pain you can get after a dental or surgical operation), treat painful menstrual cycles, reduce the number of colon and rectum growths (colorectal polyps) in patients with a disease called Familial Adenomatous Polyposis (FAP). FAP is an inherited disease in which the rectum and colon are covered with many polyps. Celebrex is used along with the usual care for FAP patients such as surgery and exams of the rectum and colon. Celecoxib does not prevent the progression of either type of arthritis. It reduces only the symptoms and signs of arthritis.
Anti-inflammatory medications such as Celebrex or aspirin interrupt the body's natural inflammation response by blocking an enzyme called COX. This enzyme controls the production of prostaglandins, chemicals with a range of effects in the body. Recently scientists discovered there are two kinds of COX, and each does something a little different. COX-1 regulates prostaglandins that protect the mucous lining of the stomach (so that the acids you use to digest food don't break down your stomach as well). COX-2 produces the prostaglandins that cause the inflammation associated with arthritis. Most NSAIDs block both types of COX, which is why aspirin is harsh on the stomach.
Celebrex medicine is believed to fight pain and inflammation by inhibiting the effect of a natural enzyme called COX-2. Unlike the older medications, however, it does not interfere with a similar substance, called COX-1, which exerts a protective effect on the lining of the stomach. Therefore, Celebrex may be less likely to cause the bleeding and ulcers that sometimes accompany sustained use of the older NSAIDs. By selectively blocking only COX-2, they are somewhat easier on the stomach than most anti-inflammatory medications.
Prostaglandins are chemicals that are important contributors to the inflammation of arthritis that causes the pain, fever, swelling and tenderness. Celecoxib, substane in Celebrex tablets, blocks the enzyme that makes prostaglandins (cyclooxygenase 2), resulting in lower concentrations of prostaglandins. As a consequence, inflammation and its accompanying pain, fever, swelling and tenderness are reduced. Celecoxib differs from other NSAIDs in that it causes less inflammation and ulceration of the stomach and intestine (at least with short-term treatment) and does not interfere with the clotting of blood.
Directions for use:
When you buy Celebrex, you can either take a full day's worth at once or in two separate doses, depending on what your doctor prescribes. Although you can take it anytime, mealtimes may be best because Celebrex dissolves more thoroughly in fat than in water. Its concentration in the bloodstream peaks about three hours after you've taken it, so that's when you'll feel the effect most. If you eat a very fatty meal before taking it, the drug's absorption is slower but more of the dose gets into your bloodstream. If you take antacids containing aluminum or magnesium with your meals, they will limit your absorption of the drug and you may not feel the full effect.
Celebrex belongs to a group of pain relief medications.
Celebrex Safety Info
Tell your healthcare professional about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Some medicines may affect how Celebrex works or Celebrex may affect how your other medicines work.
Celebrex 100mg may not be right for you, if you have had ulcers or stomach bleeding, have had asthma, hives or allergic-type reactions after taking aspirin or other NSAIDs, have severe kidney problems, have severe liver problems, are pregnant.
If you miss a dose take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at the same time.
The chance of developing a stomach ulcer or bleeding while taking Celebrex tablets increases if you also take steroid drugs or blood thinners, smoke, drink alcohol, or use Celebrex drug or other NSAID medications for a long time. The risk is also greater if you're older or in poor health.
- Osteoarthritis: 200 mg taken as a single dose or in 100 mg dose twice a day
- Rheumatoid Arthritis: 100-200 mg twice a day
- Acute Pain and Menstrual Cramps: 400 mg
- Familial Adenomatous Polyposis: 400 mg twice a day
Celebrex Side Effects
- sinus inflammation
- stomach pain