Dumirox (fluvoxamine maleate)
Dumirox is used to treat obsessive-compulsive disorder. Once a medicine has been approved for marketing for a certain use, experience may show that it is also useful for other medical problems. This medicine may also be used for mental depression and other conditions as determined by your doctor.
Dumirox belongs to a group of medicines known as selective serotonin reuptake inhibitors (SSRIs). These medicines are thought to work by increasing the activity of a chemical called serotonin in the brain.
The mechanism of action of fluvoxamine maleate in Obsessive Compulsive Disorder is presumed to be linked to its specific serotonin reuptake inhibition in brain neurons. In preclinical studies, it was found that fluvoxamine inhibited neuronal uptake of serotonin.
Obsessive Compulsive Disorder is characterized by recurrent and persistent ideas, thoughts, impulses or images (obsessions) that are ego-dystonic and/or repetitive, purposeful, and intentional behaviors (compulsions) that are recognized by the person as excessive or unreasonable.
Directions for use:
Dumirox (fluvoxamine) may be taken with or without food or on a full or empty stomach. However, if your doctor tells you to take the medicine a certain way, take it exactly as directed.
Take this medicine only as directed by your doctor to benefit your condition as much as possible. The dose of fluvoxamine will be different for different patients. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.
Several weeks (up to 8 weeks) may pass before you feel the full effect of this medicine. If you are taking fluvoxamine for obsessive-compulsive disorder, you may have to take it for up to 10 or 12 weeks before you begin to feel better. Continue to take this medicine even if you start feeling better.
If you miss a dose of fluvoxamine and your dosing schedule is: One time a day - Take the missed dose as soon as possible if remembered the same day and go back to your regular dosing schedule. Do not double doses. If two times a day - Skip the missed dose and go back to your regular dosing schedule. Do not double doses. In managing overdosage, consider the possibility of multiple drug involvement. Symptoms of overdose may be more severe than usual side effects, or two or more may occur together.
The recommended starting dose for fluvoxamine maleate is 50 mg, administered as a single daily dose at bedtime. Consequently, the dose should be increased in 50 mg increments every 4 to 7 days, as tolerated, until maximum therapeutic benefit is achieved, not exceed 300 mg per day. It is advisable that a total daily dose of more than 100 mg should be given in two divided doses. If the doses are not equal, the larger dose should be given at bedtime.
Elderly patients and those with hepatic impairment have been observed to have a decreased clearance of fluvoxamine maleate. Consequently, it may be appropriate to modify the initial dose and the subsequent dose titration for these patient groups.
Dosage for treatment of obsessive-compulsive disorder:
Adults - At first, 50 milligrams (mg) once a day at bedtime. Your doctor may increase your dose if needed. However, the dose usually is not more than 300 mg a day. If your daily dose is higher than 100 mg, your doctor may want you to take it in two divided doses.
Children younger than 8 years of age - Use and dose must be determined by your doctor.
Children 8 to 17 years of age - At first, 25 mg once a day at bedtime. Your doctor may increase your dose if needed. However, the dose usually is not more than 200 mg a day. If your daily dose is higher than 50 mg, your doctor may want you to take it in two divided doses.
Dumirox belongs to a group of anti depressants.
Dumirox Safety Info
Before using this medicine inform your doctor or pharmacist of all prescription and over-the-counter medicine that you are taking. Inform your doctor of any other medical conditions, allergies, pregnancy, or breast-feeding. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. It is important that your doctor check your progress at regular visits, to allow for changes in your dose and to help reduce any side effects.
Along with its needed effects, a medicine may cause some unwanted effects. Side effects usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of side effects continue, are bothersome or they worry you.
Your doctor may want to see you more often if you are taking some other medicines with fluvoxamine. Certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose of these medicines or may change you to a different medicine, or other precautions may be necessary.
When you are taking fluvoxamine, it is especially important that your doctor and pharmacist know if you are taking any other medicines. Using some medicines with fluvoxamine may increase the chance of developing a rare, but very serious, unwanted effect known as the serotonin syndrome or a very serious heart problem may occur. Do not take fluvoxamine while you are taking or within 2 weeks of taking an MAO inhibitor, or you may develop severe unwanted effects. At least 14 days should be allowed between stopping treatment with one medicine and starting treatment with the other.
After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. Do not stop taking this medicine without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely. This is to decrease the chance of having discontinuation symptoms.
For children it has not been shown to cause different side effects or problems than it does in adults. Because fluvoxamine may cause weight loss or a decrease in appetite, children who will be taking fluvoxamine for a long time should have their weight and growth measured by the doctor regularly. Fluvoxamine must be used with caution in children with depression. Studies have shown occurrences of children thinking about suicide or attempting suicide in clinical trials for this medicine. In older adults fluvoxamine may be removed from the body more slowly in older adults and an older adult may receive a lower dose than a younger adult.
Avoid drinking alcohol and high doses of caffeine while taking fluvoxamine. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert, able to see clearly, or able to control your movements well.
- Adults: 50-300 mg/day
- Adolescents: 25-200 mg/day
Dumirox Side Effects
- decreased appetite
- somnolence, insomnia
- headache, dizziness, asthenia
Check with your doctor asap:
- sexual problems
- mental changes
- trouble in breathing, trouble in urinating