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Rheumatoid Arthritis and Osteoarthritis (Adults)
Immediate-release
PO 75 mg 3 times daily or 50 mg 4 times daily; do not exceed 300 mg/day.
Maintenance dose
Reduce initial dosage to 75 to 150 mg/day in elderly or disabled patients or those with renal function impairment.
Sustained-release
PO 200 mg once daily can be used in patients already stabilized on that dose.
Mild to Moderate Pain, Primary Dysmenorrhea (Adults)
PO 25 to 50 mg every 6 to 8 h as needed; do not exceed 300 mg/day.
Over-the-counter (OTC) Use
Adults
PO 12.5 mg with a full glass of liquid every 4 to 6 h. If pain or fever persists after 1 h, follow with 12.5 mg. Do not exceed 25 mg in a 4- to 6-h period or 75 mg in a 24-h period. Use the smallest effective dose.
Children
PO Do not give to children younger than 16 yr of age unless directed by a health care provider.
Mild To Severe Renal Function Impairment
Maximum recommended total daily dose is 150 mg. In patients with more severe renal function impairment (GFR less than 25 mL/min or end-stage renal impairment), the max total daily dose should not exceed 100 mg.
Hepatic Function Impairment
For patients with impaired hepatic function and serum albumin concentration less than 3.5 g/dL, the max initial total daily dose should be 100 mg.
NOTE: PO is the abbreviation for the latin, Per Os - which means "taken orally".
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