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Orlistat works in intestines and since most of it remains in the digestive tract, it is not likely to pass through breast milk. However, no studies have been done on orlistat and breastfeeding, so the manufacturer recommends that women not take the drug while nursing. Because every woman's situation is different, it's best to discuss the benefits and risks of Alli or Xenical and breastfeeding with your healthcare provider.
It is important to note, that the drug can cause vitamin deficiencies, which may be undesirable especially in women who are breastfeeding. Orlistat blocks the fat from breaking down and so they are flushed through the system along with fat soluble vitamins.
In patients with normal baseline vitamin levels before using orlistat, after using orlistat low vitamin levels occur: vitamin D in 12 percent of users, beta-carotene in 6.1 percent, vitamin E in 5.8 percent and vitamin A in 2.2 percent.
To prevent vitamin deficiency, a daily multivitamin supplement containing these nutrients is recommended. It is best to take the multivitamin at least 2 hours before or 2 hours after taking orlistat.
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