Premig (acetylsalicylate lysine + metoclopramide)
Premig (metoclopramide) is used to relieve nausea and vomiting, heartburn, stomach pain and bloating, and a persistent feeling of fullness after meals. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.
Premig works efficiently at relieving migraine attack symptoms, such as nausea, vomiting and headache.
The association between headache and gastrointestinal symptoms in migraine has been known since ancient times. Gastrointestinal symptoms in patients with migraine are not only distressing, but also hinder the absorption of oral antimigraine medication. More patients with migraine associated with nausea and vomiting, said that it impaired their ability to take oral antimigraine drugs.
Aspirin is an effective treatment for migraine, but, like all oral medications, its efficacy is reduced in migraine because of the impaired gastrointestinal motility associated with nausea and non-absorption in patients who are vomiting. The addition of metoclopramide, a potent antiemetic, not only improves the absorption of Aspirin, but also reduces the troublesome and incapacitating nausea and vomiting that so frequently accompany migraine.
Premig contains two active ingredients, lysine acetylsalicylate and metoclopramide. Lysine acetylsalicylate is a soluble form of acetylsalicyclic acid, otherwise known as aspirin. Metoclopramide is an antisickness medicine (antiemetic).
Aspirin is a painkiller that belongs to a group of medicines called non-steroidal anti-inflammatory drugs (NSAIDs). It works by blocking the action of a substance in the body called cyclo-oxygenase.
Cyclo-oxygenase is involved in the production of various chemicals in the body, some of which are known as prostaglandins. Prostaglandins are produced in response to injury or certain diseases and can cause pain, swelling and inflammation. By blocking the production of prostaglandins aspirin therefore relieves pain and inflammation, and is effective at relieving the pain of headaches and migraines.
During a migraine attack sufferers can often feel sick or vomit. Metoclopramide is used to treat this symptom of the migraine.
Metoclopramide works primarily by blocking dopamine receptors that are found in an area of the brain known as the chemoreceptor trigger zone (CTZ). The CTZ sends messages to another area of the brain, known as the vomiting centre, which in turn sends nerve messages to the gut that cause vomiting. By blocking dopamine receptors in the CTZ, metoclopramide prevents messages from being sent to the vomiting centre. This reduces the sensation of nausea and prevents vomiting.
Metoclopramide also acts in the upper gut, where it enhances the action of a chemical called acetylcholine. Increasing the action of acetylcholine results in the tightening of the muscles at the entry to the stomach, as well as relaxing the muscles at the exit of the stomach. It also increases the contraction of the muscles in the stomach itself, which speeds the passage of food through the stomach into the intestine. This physically helps to prevent vomiting, but is also useful in migraine attacks because it speeds the passage of the aspirin into the intestine, allowing it to be absorbed and relieve the headache more quickly.
That is why the combination of lysine acetylsalicylate and metoclopramide is so effective in the treatment of migraine attacks.
Directions for use:
Premig is most effective at relieving migraine when it is taken as soon as possible after the onset of an attack. Take Premig exactly as directed. Do not exceed the recommended dose of this medicine.
Premig belongs to a group of head ache medications.
Premig Safety Info
Before taking metoclopramide, tell your doctor or pharmacist if you are allergic to metoclopramide or any other drugs and also what prescription and nonprescription medications you are taking, especially amobarbital (Amytal), insulin, narcotics (pain medications), phenobarbital, sedatives, tranquilizers, herbal medicines and vitamins.
This medicine should not be used if you are allergic to one or any of its ingredients. If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Consult with your doctor if you have or have ever had an adrenal tumor, a seizure disorder, Parkinson's disease, high blood pressure, heart, liver, or kidney disease, a history of mental illness or depression, life long inherited blood diseases, or an intestinal blockage or bleeding.
Use with caution if you have abnormally heavy menstrual bleeding, asthma, epilepsy, or if you consume large quantities of alcohol. Do not use Premig if you have bleeding disorders.
There is an increased risk of side effects if aspirin is taken with other non-steroidal anti-inflammatory drugs (NSAIDs). For this reason, aspirin should not be taken with any other NSAID. Also there may be an increased risk of bleeding if aspirin is taken with other 'blood-thinning' (antiplatelet) medicines, or corticosteroids.
Always inform your doctor if you are pregnant, planning a pregnancy or are breast-feeding, before using any medicine. This medicine must not be used during the third trimester of pregnancy, as it may be harmful to the unborn child. It should be used with caution in the first and second trimesters, and only if the benefits to the mother outweigh any possible risks to the baby. This medicine passes into breast milk. Women who are breastfeeding should not use this medicine.
If you are having surgery, including dental surgery, tell the doctor or dentist that you are taking metoclopramide.
You should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you. Remember that alcohol can add to the drowsiness caused by this drug.
Medicines and their possible side effects can affect individual people in different ways. Although side effects from metoclopramide are not common, they can occur. Tell your doctor if any of unwanted symptoms are severe or do not go away. If you experience any of the following symptoms, call your doctor immediately: involuntary movements of the limbs or eyes; spasm of the neck, face, and jaw muscles; change in mood (depression).
- 3 sachets/day (1620 + 10mg/sachet)
Premig Side Effects