|
When Prozac is taken with lithium, certain seizure medications, triptans, or other medications, drug interactions could occur. When these interactions occur, drug levels in your blood can increase significantly and your risks for developing side effects (such as stomach bleeding or serotonin syndrome) may be higher. Other medications that may potentially lead to drug interactions with Prozac include diazepam, monoamine oxidase inhibitors, warfarin, and nonsteroidal anti-inflammatory drugs.
The following sections explain in detail the potentially negative interactions that can occur when Prozac is combined with any of the drugs listed below.
Alprazolam (Xanax)
Taking Prozac with alprazolam can increase the level of alprazolam in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of alprazolam.
Aspirin
Taking Prozac and aspirin together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking aspirin and Prozac together.
Certain Antipsychotic Medications
Prozac can increase the level of certain antipsychotic medications in your blood and can increase your risk of side effects. Your healthcare provider may need to lower your dose of antipsychotic medicine.
Pimozide and thioridazine should never be taken with Prozac. In fact, you should not take thioridazine if you have taken Prozac within the past five weeks.
Certain Seizure Medications
Taking Prozac with certain seizure medications (carbamazepine and phenytoin) can increase the level of the seizure medication in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of seizure medication.
Diazepam (Valium)
Taking Prozac with diazepam can increase the level of diazepam in your blood, increasing your risk of side effects. Your healthcare provider may need to decrease your dose of diazepam.
Digoxin (Digitek, Lanoxin)
Taking Prozac and digoxin together can increase your risk of digoxin side effects. Your healthcare provider may need to adjust your digoxin dose when starting or stopping Prozac.
Linezolid (Zyvox)
Taking Prozac with a linezolid can cause a group of symptoms called serotonin syndrome. These symptoms include confusion, hallucination, fast heartbeat, feeling faint, fever, sweating, muscle spasm, difficulty walking, and diarrhea. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any of these symptoms, as serotonin syndrome can be very dangerous.
Lithium (Eskalith, Lithobid)
Prozac may increase or decrease the level of lithium in your blood, perhaps making it less effective or increasing your risk of side effects. Also, taking Prozac with lithium can cause serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
Monoamine Oxidase Inhibitors (MAOIs)
Taking Prozac and an MAOI together can cause life-threatening side effects. Never take an MAOI and Prozac at the same time, and do not take Prozac if you have taken an MAOI within the past 14 days. Also, because Prozac stays in your system for so long, do not take an MAOI if you have taken Prozac within the past five weeks.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking Prozac and NSAIDs together can increase your risk of stomach bleeding. Talk to your healthcare provider before taking NSAIDs and Prozac together.
SSRI or SNRI Antidepressants
Taking Prozac with other SSRI or SNRI antidepressants can cause serotonin syndrome. Talk to your healthcare provider before taking these depression medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
St. John's Wort
Taking Prozac with St. John's wort can cause serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
Tramadol (Ultram, Ultracet)
Taking Prozac with a tramadol can cause serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
Tricyclic Antidepressants
Taking Prozac with tricyclic antidepressants can increase the level of tricyclic antidepressants in your blood. Your healthcare provider may need to reduce your dose of the tricyclic antidepressant.
Triptans
Taking Prozac with a triptan can cause serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
Tryptophan
Taking Prozac with a tryptophan can cause serotonin syndrome. Talk to your healthcare provider before taking these medications together. Call your healthcare provider right away if you have any symptoms of serotonin syndrome, as it can be very dangerous.
Warfarin
Taking both Prozac and warfarin together may increase your risk of bleeding in the stomach or intestines. Your healthcare provider may choose to monitor you more closely when you are starting or stopping Prozac.
Final Thoughts
It is possible that not every drug interaction with Prozac was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific drug interactions that may apply to your situation.
|
