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Zyban is a nicotine-free quit-smoking aid. Instead of nicotine, it contains the same active ingredient Bupropion as the antidepressant medication Wellbutrin. It works by boosting the levels of several chemical messengers in the brain. If Zyban is used with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zyban with the following:
Cyclophosphamide: While it is thought that cyclophosphamide may interact with Zyban, there have been no reports of such an interaction in actual patients. Depending on your situation, if you are taking cyclophosphamide along with Zyban, your healthcare provider may choose to monitor you more closely and may adjust your doses of these medications.
Doxorubicin: Doxorubicin may raise the level of Zyban in your blood, which may increase your chances of side effects. Your healthcare provider may need to decrease your Zyban dose while you are taking doxorubicin.
Steroids: Taking Zyban with intravenous (IV) or oral steroids can increase your risk of seizures. Talk with your healthcare provider before taking these medications together.
Theophylline: Taking Zyban with theophylline can increase your risk of seizures. Talk with your healthcare provider before combining these medications.
Orphenadrine: While it is thought that orphenadrine may interact with Zyban, there have been no reports of such an interaction in actual patients. If you are taking orphenadrine along with Zyban, your healthcare provider may need to monitor you more closely and may choose to adjust your doses of these medications.
Alcohol: It is not recommended that you drink alcohol while taking Zyban. Combining the two may cause unwanted side effects (see Zyban and Alcohol). However, since stopping alcohol abruptly while taking Zyban can increase your risk of seizures, you should talk with your healthcare provider before you stop drinking alcohol.
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