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The most commonly observed adverse events associated with the use of paroxetine in treating Major Depressive Disorder (incidence of 5% or greater) were: asthenia, sweating, nausea, decreased appetite, somnolence, dizziness, insomnia, tremor, nervousness, ejaculatory disturbance, and other male genital disorders.
The most commonly observed adverse events associated with the use of paroxetine in treating Obsessive Compulsive Disorder (incidence of 5% or greater) were: Nausea, dry mouth, decreased appetite, constipation, dizziness, somnolence, tremor, sweating, impotence, and abnormal ejaculation.
The most commonly observed adverse events associated with the use of paroxetine in treating Panic Disorder (incidence of 5% or greater) were: Asthenia, sweating, decreased appetite, libido decreased, tremor, abnormal ejaculation, female genital disorders, and impotence.
The most commonly observed adverse events associated with the use of paroxetine in treating Social Anxiety Disorder (incidence of 5% or greater) were: Sweating, nausea, dry mouth, constipation, decreased appetite, somnolence, tremor, libido decreased, yawn, abnormal ejaculation, female genital disorders, and impotence.
The most commonly observed adverse events associated with the use of paroxetine in treating Generalized Anxiety Disorder (incidence of 5% or greater) were: Asthenia, infection, constipation, decreased appetite, dry mouth, nausea, libido decreased, somnolence, tremor, sweating, and abnormal ejaculation.
The most commonly observed adverse events associated with the use of paroxetine in treating Posttraumatic Stress Disorder (incidence of 5% or greater) were: Asthenia, sweating, nausea, dry mouth, diarrhea, decreased appetite, somnolence, libido decreased, abnormal ejaculation, female genital disorders, and impotence.
Adaptation to certain adverse events
Over a 4- to 6-week period, there was evidence of adaptation to some adverse events with continued therapy (e.g., nausea and dizziness), but less to other effects (e.g., dry mouth, somnolence, and asthenia).
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