Seroxat (paroxetine hydrocloride)
Seroxat is a treatment for adults with Depression, Generalised anxiety disorder (GAD), A psychiatric disorder in which tasks are excessively repeated (obsessive-compulsive disorder), Condition of sudden attacks of fear, panic and confusion (panic disorder), Post-traumatic stress disorder, Fear of social situations (social phobia) and it can also be used in the treatment of premature ejaculation, chronic headaches and bipolar disorder.
Seroxat tablets contain the active ingredient paroxetine or paroxetine hydrochloride which is a type of antidepressant known as a selective serotonin reuptake inhibitor (SSRI). It was released in 1992 by pharmaceutical company Glaxo Smith Kline and has become one of the most prescribed most potent antidepressants on the market.
Everyone has a substance called Serotonin in their brain. In the brain there are numerous different chemical compounds called neurotransmitters. These act as chemical messengers between the nerve cells. Serotonin is one such neurotransmitter and has various functions that we know of. People who are depressed or anxious have lower levels of serotonin than others, thus low levels of serotonin in the brain are thought to be a cause of depression and other related conditions. When serotonin is released from nerve cells in the brain it acts to lighten mood. When it is reabsorbed into the nerve cells, it no longer has an effect on mood. It is thought that when depression occurs, there may be a decreased amount of serotonin released from nerve cells in the brain. Seroxat works by bringing the levels of serotonin back to normal. SSRI's work by preventing serotonin from being reabsorbed back into the nerve cells in the brain. This helps prolong the mood lightening effect of any released serotonin. In this way, paroxetine helps relieve depression, panic and fear.
Directions for use:
Like other drugs of this type, Seroxat will not relieve your symptoms straight away. You should be aware that this medicine may not start to make you feel better for at least two to four weeks. However, it is important that you keep taking it in order for it to work properly and for you to feel better, even if it doesn't seem to make much of a difference at first. Some people taking antidepressants feel worse before feeling better. Even after you start to feel better it's important to keep taking your tablets for as long as your doctor recommends, as this will prevent your symptoms from returning. If you feel your depression or anxiety has got worse, or if you have any distressing thoughts, or feelings about suicide or harming yourself in these first few weeks, or indeed at any point during treatment or after stopping treatment, then it is very important to talk to your doctor.
By continuing to take your tablets even when you begin to feel better, Seroxat will prevent your symptoms from returning. This will be at least four to six months after you have recovered from your depression and may be even longer for obsessions and compulsions or panic disorder. Remember that you cannot become addicted to Seroxat.
Take your medicine at the same time every day. It is recommended that you take your dose of this medicine in the morning, with or after food. If you miss a dose, leave out that dose completely. Take your next dose at the normal time. You should never take more tablets than your doctor recommends. Be cautilous about overdose. If you take too many Seroxat tablets, tell your doctor or hospital casualty department straight away. It is important to take the tablets each day until they are finished. Don’t stop taking Seroxat without talking to your doctor. If you stop taking Seroxat suddenly or miss a dose, you may get withdrawal effects.
You may find it helpful to tell a friend or relative that you are depressed or suffering from an anxiety disorder, and you might ask them to tell you if they think your depression or anxiety is getting worse, or if they are worried about changes in your behaviour.
Remember, your doctor will advise you on the daily dose you should take and how long you will need to keep taking your medicine.
Seroxat belongs to a group of anti depressants.
Seroxat Safety Info
Always tell your doctor about any medicines you are taking. Seroxat may interact with some drugs and this can cause problems and unwanted effects. The dose may need to be changed or you may need to be given another medicine. This medicine should not be used if you are allergic to paroxetine or any other ingredients. You should not take Seroxat if you are taking monoamine oxidase inhibitors (MAOIs), or if you have taken them within the last two weeks.
Make sure your doctor knows all about your medical history so he can make the best and safe solution for you. If you have trouble with your liver or kidneys, diabetis, epilepsy or heart disease, your doctor may decide that you should have a lower dose of Seroxat than usual. If you have severe liver or kidney disease the maximum dose is 10 ml (20 mg of paroxetine) per day. Seroxat should not be used for children and adolescents under 18 years. In patients with manic depression or uncontrolled epilepsy. Certain groups of patients may be more likely to think about suicide or harming yourself - young adults and those who have previously had thoughts about killing yourself. If you feel restless and feel like you can’t sit or stand still, tell your doctor. Increasing the dose of Seroxat may make these feelings worse.
Most people find that Seroxat does not affect their normal daily lives. But, as with many medicines, you should take extra care when you are driving or operating machinery. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance. Also do not drink alcohol while you are taking Seroxat. Alcohol may make your symptoms or side-effects worse.
If you are already taking Seroxat and have just found out that you are pregnant, you should talk to your doctor immediately. Some studies have suggested an increase in the risk of heart defects and other side effects in babies. You and your doctor may decide that it is better for you to gradually stop taking Seroxat while you are pregnant. However, depending on your circumstances, your doctor may suggest that it is better for you to keep taking Seroxat. Seroxat may get into breast milk. You and your doctor will decide if you can or can not breast-feed while you are taking Seroxat.
Any medicine can cause unwanted side-effects, but not everybody gets them. It is therefore important that you and your doctor weigh up the benefits of treatment against the possible unwanted effects, before starting treatment. With Seroxat, most side effects are mild and usually go away after the first few weeks of treatment. The most likely side effect of Seroxat is that you may feel slightly sick. Taking your medicine in the morning after food will reduce the chances of this happening. If any of unwanted side-effects persist or worsen, contact your doctor or pharmacist promptly.
When stopping Seroxat, your doctor will help you to reduce your dose slowly over a number of weeks or months – this should help reduce the chance of withdrawal effects. One way of doing this is to gradually reduce the dose of Seroxat you take by 5 ml (10 mg of paroxetine) a week. Some people find that if they suddenly stop taking these tablets, they feel dizzy, shaky, sick, anxious, agitated, confused, they may experience tingling sensations and headaches. They may also have difficulty sleeping and vivid dreams when they do sleep. Most people find that any symptoms on stopping Seroxat are mild and go away on their own within two weeks. For some people, these symptoms may be more severe, or go on for longer. If you get severe withdrawal effects when you are coming off your medicine your doctor may decide that you should come off it more slowly.
- Depression: Starting Dose: 20 mg, Recommended daily dose: 20 mg
- Obsessive Compulsive Disorder: Starting Dose: 20 mg, Recommended daily dose: 40 mg
- Panic Disorder: Starting Dose: 10 mg, Recommended daily dose: 40 mg
- Social Anxiety Disorder: Starting Dose: 10 ml, Recommended daily dose: 20 mg
- Post Traumatic Stress Disorder: Starting Dose: 20 mg, Recommended daily dose: 20 mg
- Generalised Anxiety Disorder: Starting Dose: 20 mg, Recommended daily dose: 20 mg
Maximum daily dose is 50 mg. The maximum dose for people over 65 is 40 mg per day. To help you adjust to this dosage in stages, you should take a gradually increasing number of tablets over a period of two to four weeks.
Seroxat Side Effects
- decreased appetite
- sleepiness or insomnia
- sexual problems
- fast heartbeat
- urinary incontinence