|
Testosterone enanthate is a derivative of the primary endogenous androgen testosterone, for intramuscular administration. Endogenous androgens are responsible for the normal growth and development of the male sex organs and for maintenance of secondary sex characteristics. These effects include growth and maturation of prostate, seminal vesicles, penis, and scrotum; development of male hair distribution, such as beard, pubic, chest and axillary hair; laryngeal enlargement; vocal chord thickening; alterations in body musculature; and fat distribution.
Androgens, like Testosterone Enanthate also cause retention of nitrogen, sodium, potassium, and phosphorus, and decreased urinary excretion of calcium. Androgens have been reported to increase protein anabolism and decrease protein catabolism. Nitrogen balance is improved only when there is sufficient intake of calories and protein.
Testosterone Enanthate is responsible for the growth spurt of adolescence and for the eventual termination of linear growth which is brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoietic stimulating factor.
During exogenous administration of Testosterone Enanthate, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). At large doses of exogenous androgens, spermatogenesis may also be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).
Studies aimed at assessing a possible tumorigenic effect following repeated administration have not been performed with Testosterone Enanthate. In addition, many years of clinical experience with Testosterone Enanthate have not given any indications of a tumorigenic effect in humans. Generally, however, it has to be remembered that naturally occurring as well as synthetically produced sexual steroids can promote the growth of certain hormone-dependent tissues and tumours.
|
