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Some of the medications that may cause drug interactions with diclofenac products include cyclosporine, methotrexate, ACE inhibitors, and anticoagulant or antiplatelet drugs. These interactions could increase your risk for developing certain side effects or complications, such as internal bleeding or kidney damage.
The following section explain in detail the potentially negative interactions that can occur with diclofenac.
ACE Inhibitors
Diclofenac might reduce the effectiveness of ACE inhibitors for lowering blood pressure and may also increase the risk of kidney damage. If you take diclofenac with an ACE inhibitor, your healthcare provider should monitor your blood pressure to watch for this interaction.
Anticoagulant or Antiplatelet Medications
Combining diclofenac with other medications that have anticoagulant or antiplatelet activity (commonly described as "blood thinners") might increase the risk of bleeding, including dangerous internal bleeding. Check with your healthcare provider before taking diclofenac with any such medications (even non-prescription ones).
Certain Diuretics
Diclofenac may decrease the effectiveness of many diuretics. Additionally, combining diclofenac with a diuretic may increase the risk of kidney damage. If you take such medications together, your healthcare provider should monitor your kidney function and should make sure that your diuretic is still working well.
Cyclosporine
Combining cyclosporine with diclofenac may increase the risk of kidney damage. If you must take these medications together, your healthcare provider should monitor your kidney function closely to watch for any potential problems.
Lithium
Combining lithium with diclofenac may increase the level of lithium in the blood, perhaps causing lithium toxicity. If you take diclofenac with lithium, your healthcare provider should monitor you closely to watch for this interaction.
Methotrexate
Diclofenac might increase the risk of methotrexate side effects. Check with your healthcare provider before combining these two medications.
It is possible that not all drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific interactions that may apply to you.
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