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Winstrol (stanozolol) has substantial fibrinolytic properties, and has been effective in the treatment of urticaria, Raynaud's phenomenon, cryptofibrinogenemia, and lipodermatosclerosis. Winstrol has also effected cures of osteonecrosis in cases resistant to all other therapy and has been used successfully in treatment of AIDS wasting syndrome. Winstrol is also useful in treatment of hereditary angioedema.
Winstrol use is contraindicated in the following:
- Nephrosis or the nephrotic phase of nephritis
- Males with carcinoma of the breast, or with known or suspected carcinoma of the prostate
- Carcinoma of the breast in females with hypercalcemia; Winstrol may stimulate osteolytic resorption of bone
- Winstrol is contraindicated in women who are or may become pregnant. If Winstrol is used during pregnancy, or if female becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus
Periodic, every 6 months x-ray examinations of bone age should be made during treatment of prepubertal patients with Winstrol to determine the rate of bone maturation and the effects of androgenic anabolic steroid therapy on the epiphyseal centers.
In common with other anabolic steroids, Winstrol has been reported to raise the level of low-density lipoproteins and lower the level of high-density lipoproteins. These changes usually revert to normal on discontinuation of treatment with Winstrol. Decreased high-density lipoproteins and increased low-density lipoproteins are considered cardiovascular risk factors. Serum lipids and high-density lipoprotein cholesterol should be determined periodically. Also hemoglobin and hematocrit should be checked periodically for polycythemia in patients who are receiving high doses of Winstrol.
Winstrol may increase sensitivity to anticoagulants; therefore, dosage of an anticoagulant may have to be decreased in order to maintain the prothrombin time at the desired therapeutic level. Therapy with Winstrol may decrease levels of thyroxine-binding globulin resulting in decreased total T4 serum levels and increase resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged during treatment and there is no clinical evidence of thyroid dysfunction.
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