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Zyban (bupropion) reduces the craving for smoking and so helps you to stop smoking. Its exact mechanism of action is not fully understood, but it is believed that it interacts with chemicals in the brain called noradrenaline and dopamine, which are associated with craving and withdrawal.
Studies have shown that a significant number of people managed to remain smoke-free for at least 6 months while taking Zyban. For many patients, Zyban reduces withdrawal symptoms and the urge to smoke.
There have been only two published studies on Zyban. The first study of 615 (non-depressed) smokers showed 23.1% patients treated with Zyban were not smoking at one year, compared to 12.4% with placebo. The second study of 893 smokers undertook a direct comparison with NRT (nicotine patch). This study found that Zyban is almost twice as effective as a nicotine patch.
Results from these two multi-centre studies show that Zyban is an effective aid to smoking cessation and demonstrate that patients treated with Zyban have a greater chance of quitting smoking than patients treated with placebo or a nicotine patch.
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